1.First and foremost, you have to try the Grilled Local Sea Bass with Calamari and Mussels at The Bristol Hotel's very own, FIRSTavenue bar & grille. It's some of the best seafood San Diego has to offer. After trying FIRST, venture to Donovan's Prime Seafood, less than a mile away. This chic spot, with its sharp decor and focus on sustainability, is one of the best San Diego seafood restaurants, a hit with locals and travelers alike. Ocean Room is also just a half-mile away, in the heart of the Gaslamp District. The sushi and oyster bar overlooks an open kitchen, while their shellfish is infamously perfect and kettle-steamed to order. For a more eccentric hole-in-the-wall experience, try Escape Fish Bar, a laid back spot with locally caught seafood, local beer, and local wine. All the fish dishes they offer are globally inspired, but their fish and chips are the best in the city.